Objective To analyze the influencing factors of patient reported outcomes in patients with stable chronic obstructive pulmonary disease (COPD) and the correlation with inflammatory indexes,so as to provide the reference for the early nursing intervention with the focus of patients. Methods The convenience sampling method was used to select outpatients with stable COPD from the department of respiratory clinic of a tertiary hospital in Nanning from October 2020 to July 2021. Questionnaires,including a general information questionnaire and the revised version of the Chronic Obstructive Pulmonary Disease Patient Reported Outcome Scale (mCOPD-PRO),were used to collect the results of inflammatory response indicators at the time. Results A total of 204 patients with stable COPD were included,with the mCOPD-PRO score of (1.75±0.58). Multiple regression analysis showed that the factors influencing the patient reported outcomes with stable COPD were gender,the number of comorbidities,disease duration,and lung function grading (P<0.05),which explained 10.8 % of the variance. There were positive correlations between patient reported outcomes with stable COPD and white blood cell count (WBC),neutrophil count (NEU),and eosinophil count (EOS) (P<0.05). There were negative correlations between patient reported outcomes with stable COPD and total albumin (TP) (P<0.05). Conclusion The health level of patients reported outcomes in stable COPD needs to be improved. Female patients,patients with comorbidities>3,longer duration and worse lung function reported lower levels of health. Patient reported outcomes with COPD are closely related to the levels of serum WBC,NEU,EOS and TP. Medical staff should pay more attention to patients reported outcomes and inflammatory indexes in stable COPD,and take targeted intervention measures in the early stage to improve the quality of life of patients.